Dob7^AKR/J
QTL Variant Detail

Summary

• QTL variant: Dob7^AKR/J
• Name: dietary obesity 7; AKR/J
• MGI ID: MGI:2446880
• QTL: Dob7 Location: unknown Genetic Position: ChrX, cM position of peak correlated region/allele: 57.38 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: AKR/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased body weight and adiposity compared to SWR/J.
• Inheritance: Not Specified

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome X, Atp6ap1 (29.8 cM), Flna (29.8 cM), and Gdi1 (29.8 cM) all show differential expression between A/a and A/A^vy animals on the restricted diet. Diabesity QTLs Bw19 (26.4 cM) and C10bw6 (32 cM) map near these candidate genes. Jarid1c (64 cM) shows differential expression between the restricted and unrestricted diets on the A/A^vy background. Diabesity QTL Dob7 (59.5 cM) maps near Jarid1c.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:43487

A subset of 187 F2 mice from an AKR/J x SWR/J cross were analyzed for various parameters effecting body weight and associated LOD scores were calculated for loci on the mouse X Chromosome. A quantitative trait locus (QTL), Dob7, was significantly associated on the X Chromosome approximately 2 cM distal of DXMit174.

References

• Original: J:43487 York B, et al., Inherited non-autosomal effects on body fat in F2 mice derived from an AKR/J x SWR/J cross. Mamm Genome. 1997 Oct;8(10):726-30
• All: 1 reference(s)