Gct1^SWR/Bm
QTL Variant Detail

Summary

• QTL variant: Gct1^SWR/Bm
• Name: granulosa cell tumorigenesis 1; SWR/Bm
• MGI ID: MGI:2446889
• Synonyms: Gct^s
• QTL: Gct1 Location: Chr4:144784226-144784343 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 78.17 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SWR/Bm

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to granulosa cell tumor formation compared to SJL. (J:49710)
• Inheritance: Dominant

Tumor Data

List all tumor models in MMHCdb carrying Gct1^SWR/Bm

Notes

Granulosa cell tumor susceptibility (Gct) controls granulosa cell carcinoma formation in response to dehydroepiandrosterone (DHEA) treatment. Spontaneous ovarian granulosa cell (GC) carcinomas occur in the inbred strain SWR/Bm and in three SWXJ recombinant inbred strains. Dehydroepiandrosterone (DHEA) treatment of the SWXJ recombinant inbred (RI) strains and of the progenitor strains SWR/Bm and SJL/Bm caused an increase in GC tumor incidence in SWR and in the RI strains that produced tumors spontaneously, and also caused tumors in five RI strains that had not previously produced GC tumors. The other SWXJ strains and the SJL/Bm progenitor strain did not produce tumors (J:9301).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49710

The authors analyzed the F2 female progeny from four reciprocal F1 x F1 intercrosses [cross A. (SJL x SWR)F1 x (SJL x SWR)F1; cross B. (SJL x SWR)F1 x (SWR x SJL)F1; cross C. (SWR x SJL)F1 x (SJL x SWR)F1; cross D. (SWR x SJL)F1 x (SWR x SJL)F1] for granulosa cell (GC) tumors at 8 weeks of age to identify QTLs. D4Mit232 yielded the highest significance level of association GC tumorigenesis (chi square = 41.18; P<0.0001). The distal boundary of significant association with Gct has not been defined because of insufficient polymorphisms between SWR and SJL for loci distal to D4Mit190. The authors also found that at least one SWR-derived Gct allele is required for tumorigenesis and that this loci behaves like an oncogene with the SWR allele acting in a dominant fashion.

References

• Original: J:49710 Beamer WG, et al., Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res. 1998 Aug 15;58(16):3694-9
• All: 3 reference(s)