Gct3^SWR
QTL Variant Detail

Summary

• QTL variant: Gct3^SWR
• Name: granulosa cell tumorigenesis 3; SWR
• MGI ID: MGI:2446894
• QTL: Gct3 Location: Chr15:64409596-64409691 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 29.03 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SWR

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49710

The authors analyzed the F2 female progeny from four reciprocal F1 x F1 intercrosses [cross A. (SJL x SWR)F1 x (SJL x SWR)F1; cross B. (SJL x SWR)F1 x (SWR x SJL)F1; cross C. (SWR x SJL)F1 x (SJL x SWR)F1; cross D. (SWR x SJL)F1 x (SWR x SJL)F1] for granulosa cell (GC) tumors at 8 weeks of age to identify QTLs. D15MIT133 yielded a significant level of association GC tumorigenesis (chi square = 11.38; P<0.0003). The authors suggest that the Gct locus modifies tumor susceptibility but is not required for tumorigenesis.

References

• Original: J:49710 Beamer WG, et al., Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res. 1998 Aug 15;58(16):3694-9
• All: 1 reference(s)