Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
This allele, in conjunction with homozygosity for BALB/c-derived alleles at Lmr1, confers susceptibility to Leishmania major infection.
Mapping and Phenotype information for this QTL, its variants and associated markersJ:57691In mice, susceptibility to Leishmania major infection is genetically controlled with BALB/c mice being susceptible and C57BL/6 mice being resistant. Previous studies have revealed the presence of two QTLs Lmr1 and Lmr2 (see J:40874). Analysis of the data from the crosses implicated the presence of a X-Chromosome QTL with a dominantly acting C57BL/6 susceptibility allele. Employing a strategy to identify interacting loci, the authors were able to show that Lmr1 and Lmr2 interact synergistically as well as describe the presence of a new locus Lmr30 on the X Chromosome mapping with marker DXMit170 with a Z score of 3.9. [Fig.1.] The C57BL/6 allele at Lmr30 acts dominantly to cause susceptibility in the presence of homozygosity for the BALB/c allele at the Lmr1 locus. Tnfsf5 is a possible candidate for the Lmr30 QTL. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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