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Lmr30C57BL/6
QTL Variant Detail
Summary
QTL variant: Lmr30C57BL/6
Name: leishmaniasis resistance 30; C57BL/6
MGI ID: MGI:2446900
QTL: Lmr30  Location: ChrX:102062606-102062720 bp  Genetic Position: ChrX, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to leishmaniasis compared to BALB/c in conjunction with Lmr1. (J:57691)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
This allele, in conjunction with homozygosity for BALB/c-derived alleles at Lmr1, confers susceptibility to Leishmania major infection.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:57691

In mice, susceptibility to Leishmania major infection is genetically controlled with BALB/c mice being susceptible and C57BL/6 mice being resistant. Previous studies have revealed the presence of two QTLs Lmr1 and Lmr2 (see J:40874). Analysis of the data from the crosses implicated the presence of a X-Chromosome QTL with a dominantly acting C57BL/6 susceptibility allele. Employing a strategy to identify interacting loci, the authors were able to show that Lmr1 and Lmr2 interact synergistically as well as describe the presence of a new locus Lmr30 on the X Chromosome mapping with marker DXMit170 with a Z score of 3.9. [Fig.1.] The C57BL/6 allele at Lmr30 acts dominantly to cause susceptibility in the presence of homozygosity for the BALB/c allele at the Lmr1 locus. Tnfsf5 is a possible candidate for the Lmr30 QTL.

References
Original:  J:57691 Roberts LJ, et al., Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection. Eur J Immunol. 1999 Sep;29(9):3047-50
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory