Lmr2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Lmr2^C57BL/6J
• Name: leishmaniasis resistance 2; C57BL/6J
• MGI ID: MGI:2446907
• QTL: Lmr2 Location: Chr9:36943406-50111140 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 23.41 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers resistance to leishmaniasis compared to BALB/c. This allele confers faster wound healing compared to BALB/cAN. (J:40874, J:102480)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:40874

Analysis of 2 sets of F2 progeny (199 and 271 animals) derived from a BALB/cAnBradleyWEH1 x C57BL/6J cross indicated the presence of quantitative trait loci (QTL) invloved with resistance to Leishmania major infection. BALB/c mice are uniformly susceptible to infection, while C57BL/6 mice are consistently resistant. One QTL, Lmr2, maps to mouse Chromosome 9 between loci D9Mit67 and D9Mit71.

References

• Original: J:40874 Roberts LJ, et al., Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J Exp Med. 1997 May 5;185(9):1705-10
• All: 3 reference(s)