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Lmr1BALB/c
QTL Variant Detail
Summary
QTL variant: Lmr1BALB/c
Name: leishmaniasis resistance 1; BALB/c
MGI ID: MGI:2446908
QTL: Lmr1  Location: Chr17:10081340-86996400 bp  Genetic Position: Chr17, cM position of peak correlated region/allele: 20.67 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  BALB/c
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsThis allele confers susceptibility to leishmaniasis compared to C57BL/6J. This allele confers slower wound healing compared to C57BL/6J. (J:40874, J:102480)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:40874

Analysis of 2 sets of F2 progeny (199 and 271 animals) derived from a BALB/cAnBradleyWEH1 x C57BL/6J cross indicated the presence of quantitative trait loci (QTL) involved with resistance to Leishmania major infection. BALB/c mice are uniformly susceptible to infection, while C57BL/6 mice are consistently resistant. One QTL, Lmr1, maps to mouse Chromosome 17 between loci D17Mit11 and D17Mit115.

References
Original:  J:40874 Roberts LJ, et al., Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J Exp Med. 1997 May 5;185(9):1705-10
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory