Bw11^DU6
QTL Variant Detail

Summary

• QTL variant: Bw11^DU6
• Name: body weight QTL 11; DU6
• MGI ID: MGI:2446920
• QTL: Bw11 Location: unknown Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: DU6

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A^vy background as well as between A/a and A/A^vy animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A^vy background. D15Wsu75e shows differential expression between A/a and A/A^vy animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A^vy animals on the restricted diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49578

F2-intercross pedigree analysis of progeny from crosses between a single male of the outbred mouse line DU6 (selected for high body weight) and a DUKs female (a randomly mated control line) was used to map quantitative trait loci (QTLs). A QTL linked with body weight, Bw11, was placed at 6 cM on mouse Chromosome 15. A QTL associated with liver weight, Lwq5, was placed at 33 cM.

References

• Original: J:49578 Brockmann GA, et al., Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth. Genetics. 1998 Sep;150(1):369-81
• All: 1 reference(s)