Bbaa11^C3H/HeN
QTL Variant Detail

Summary

• QTL variant: Bbaa11^C3H/HeN
• Name: B.burgdorferi-associated arthritis 11; C3H/HeN
• MGI ID: MGI:2447009
• QTL: Bbaa11 Location: Chr1:65889006-65889210 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 33.31 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeN

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:73060)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

In the (C57BL/6N X C3H/HeN)F1 X C3H/HeN backcross a novel QTL, Bbaa11, linked to ankle swelling was mapped to Chr 1 at 32.8 cM withmarker D1Mit76, LRT=14.2 accountng for 5% of trait variance. [Table 2.]

In the (C57BL/6N x C3H/HeN) x C57BL/6N backcross a novel QTL, Bbaa12, also mapped to Chr 1. This QTL was also linked to ankle swelling mapping between 92 and 100 cM, LRT=25.1 accounting for 15.1% of the variance. [Table 2.]

In the reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross another QTL was identified.

The authors equate this QTL with Bbaa12 but since Bbaa12 was mapped in the (C57BL/6N x C3H/HeN) x C57BL/6N backcross, which differs from the population of the F2 intercross used here, curators have named this QTL Bbaa30.

Bbaa30 maps to Chr 1 linked to total IgG at 92.3 cM mapping between markers D1Mit150 and D1Mit36, LRT=19.1 accounting of 0.80% variance. [Table 2.]

C3H/HeN-derived alleles are associated withincreased arthritis susceptibility and severity at all QTL mapped in this experiment.

References

• Original: J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• All: 1 reference(s)