Elnt^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Elnt^DBA/2J
• Name: escape latencies during navigation task; DBA/2J
• MGI ID: MGI:2447018
• QTL: Elnt Location: Chr1:162145207-194111528 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 80.13 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75894

26 C57BL/6J x DBA/2J (BXD) recombinant inbred (RI) strains were analyzed for loci linked to spatial abilities during the Morris navigation task. 118 polymorphic markers at an average spacing of 25 cM were screened in 6 animals of each RI strain. A locus with significant linkage to escape latencies during the Morris navigation task, Elnt, mapped to mouse Chromosome 1 with a maximun LOD = 6.23 between 90 cM (D1Mit106) - 98 cM (D1Mit155). A locus linked to spacial bias during the Morris navigation task, Sbnt1,mapped to mouse Chromosome 5 with a LOD peak of 3.72 at 61 cM between Spp1 (56 cM) and D5MitByu (68 cM). Two other loci affecting spacial bias were shown to interact with Sbnt1, one of which reached statistcal significance on mouse Chromosome 13 with LOD = 3.41 between 23 cM (D13Byu1) - 35 cM (D13Mit13) and was named Sbnt2. The other locus reached suggestive significance on mouse Chromosome 2 with LOD = 2.9 at 49 cM between D2Mc2 (48 cM) and D2Byu3 (69 cM).

References

• Original: J:75894 Milhaud JM, et al., Two QTLs located on chromosomes 1 and 5 modulate different aspects of the performance of mice of the B x D Ty RI strain series in the Morris navigation task. Behav Genet. 2002 Jan;32(1):69-78
• All: 1 reference(s)