Pbctlp1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Pbctlp1^DBA/2J
• Name: peripheral blood cytotoxic T lymphocyte percentage 1; DBA/2J
• MGI ID: MGI:2447026
• QTL: Pbctlp1 Location: Chr19:15875028-15875174 bp Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:74270

35 C57BL/6J x DBA/2J (BXD) recombinant inbred (RI) strains were used to map loci associated with peripheral blood lymphocyte proportions. Parental strain C57BL/6J exhibits a higher concentration of circulating white blood cells compared to DBA/2J. Two loci linked to peripheral blood B lymphocyte proportion, Pbbcp1 and Pbccp2, mapped to mouse Chromosome 1. Pbbcp1 spans 62 cM - 64 cM and gives strongest linkage at 63.1 cM with LOD=4.1 at D1Mit188. Pbbcp2 gives strongest linkage at 48.4 cM with LOD=3.7 at D1Ncvs45. A locus linked to peripheral blood CD8 T lymphocyte proportion, Pbctlp1, mapped to mouse Chromosome 19 from 9 cM - 24 cM with LOD=3.8 at D19Mit28 (12 cM). A (C57BL/6J x SJL)F2 intercross population was used to confirm the QTLs mapped in the BXD RI strains. Parental C57BL/6J exhibits a significantly higher concentration of circulating white blood cells compared to SJL. Pbbcp1 was detected in the F2 cross, but not Pbbcp2 or Pbctlp1. Authors speculate C57BL/6J and SJL may not be polymorphic at Pbbcp2 and Pbctlp1. In the F2 cross, Pbbcp1 spanned 59.8 cMp - 70 cM and showed strongest linkage at Gli2 (63 cM) with LOD=5.6. Possible candidate genes for Pbbcp1 are Gli2, En1, and Bcl2.

References

• Original: J:74270 Chen J, et al., Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood. Blood. 2002 Jan 15;99(2):561-6
• All: 1 reference(s)