Tg(CMV-IghvaD11)CCat
Transgene Detail
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Symbol: |
Tg(CMV-IghvaD11)CCat |
Name: |
transgene insertion C, Antonio Cattaneo |
MGI ID: |
MGI:2447027 |
Synonyms: |
AD09 C, AD11-VH, CMV-VH alphaD11, Tg(CMV-Igh@aD11)CCat, Tg(Igh)1Cat, VH-alphaD11 C |
Transgene: |
Tg(CMV-IghvaD11)CCat Location: unknown
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Alliance: |
Tg(CMV-IghvaD11)CCat page
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Strain of Origin: |
(C57BL/6 x SJL)F2
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(CMV-IghvaD11)CCat expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
rat |
Ighv (314492) |
"The gene encodes a recombined variable region from the rat anti-nerve growth factor monoclonal antibody, alphaD11." |
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Mutation details: The transgenic construct included a recombined Igh variable region encoding the heavy chain of the rat anti-nerve growth factor monoclonal antibody, alphaD11. The constant region of the human immunoglobulin heavy region (IGH@) was included downstream to enable the detection of the transgenic antibodies against murine immunoglobulins. The early region promoter (-601 to -16) of human CMV reportedly drove expression of the transgene in non-neuronal tissures as well as in neuronal tissues including the cortex, hippocampus, thalamus, spinal cord, retina, olfactory bulb, and cerebellum. Line C gave a higher transgenic heavy chain expression than line D.
(J:79946)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Founder lines C and D were generated. Expression was reported to be higher in line D than line C.
Double transgenic mice expressing both light and heavy chains of the alphaD11 antibody were generated by breeding mice harboring this transgene with mice carrying Tg(CMV-IgkvaD11)ACat.
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Original: |
J:79946 Ruberti F, et al., Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy. J Neurosci. 2000 Apr 1;20(7):2589-601 |
All: |
8 reference(s) |
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