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Tg(CMV-IghvaD11)CCat
Transgene Detail
Summary
Symbol: Tg(CMV-IghvaD11)CCat
Name: transgene insertion C, Antonio Cattaneo
MGI ID: MGI:2447027
Synonyms: AD09 C, AD11-VH, CMV-VH alphaD11, Tg(CMV-Igh@aD11)CCat, Tg(Igh)1Cat, VH-alphaD11 C
Transgene: Tg(CMV-IghvaD11)CCat  Location: unknown  
Alliance: Tg(CMV-IghvaD11)CCat page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CMV-IghvaD11)CCat expresses 1 gene
 
Mutation detailsThe transgenic construct included a recombined Igh variable region encoding the heavy chain of the rat anti-nerve growth factor monoclonal antibody, alphaD11. The constant region of the human immunoglobulin heavy region (IGH@) was included downstream to enable the detection of the transgenic antibodies against murine immunoglobulins. The early region promoter (-601 to -16) of human CMV reportedly drove expression of the transgene in non-neuronal tissures as well as in neuronal tissues including the cortex, hippocampus, thalamus, spinal cord, retina, olfactory bulb, and cerebellum. Line C gave a higher transgenic heavy chain expression than line D. (J:79946)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Founder lines C and D were generated. Expression was reported to be higher in line D than line C.

Double transgenic mice expressing both light and heavy chains of the alphaD11 antibody were generated by breeding mice harboring this transgene with mice carrying Tg(CMV-IgkvaD11)ACat.
References
Original:  J:79946 Ruberti F, et al., Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy. J Neurosci. 2000 Apr 1;20(7):2589-601
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory