Rends^NZW
QTL Variant Detail

Summary

• QTL variant: Rends^NZW
• Name: renal disease susceptibility; NZW
• MGI ID: MGI:2447057
• QTL: Rends Location: Chr2:152699221-152699361 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 75.41 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZW

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased susceptibility to renal disease compared to PL/J.

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75326

A genome scan using 75 polymorphic markers was performed on a population of (NZW/LacJ X PL/J)F1 x NZW/BlNJ animals to identify loci contributing to systemic lupus erythrematosus (SLE). Inbred strains NZW/LacJ and NZW/BlNJ are susceptible to SLE whereas PL/J is resistant. Significant linkage to mortality and proteinuria was detected on distal mouse Chromosome 2 at approximately 86 cM with a LOD score of 6.6 at D2Mit285. This locus was named Rends (author's designation: Wbw1). Rends has a QTL range of 58 cM - 93 cM and is associated with the NZW/LacJ-derived susceptibility allele. PL/J-derived alleles at Rends appear to exhibit a dominant protective effect. A possible candidate gene for Rends is Il1. Defects in Il1 expression have been observed in 2 mouse models of SLE. Rends appears to interact with NZW/LacJ-derived alleles to increase disease severity at suggestive loci on mouse Chromosome 17 (24 cM) near D17Mit177 (which the authors designate Wbw2) and distal mouse Chromosome 1 near D1Mit17 (106 cM). The Chromosome 1 locus maps near a previously identified SLE susceptibility QTL, Sle1c. A possible candidate gene identified for this region is Cr2.

References

• Original: J:75326 Rahman ZS, et al., A novel susceptibility locus on chromosome 2 in the (New Zealand Black x New Zealand White)F(1) hybrid mouse model of systemic lupus erythematosus. J Immunol. 2002 Mar 15;168(6):3042-9
• All: 2 reference(s)