Tg(IL2-Il10)1Kro
Transgene Detail

Summary

• Symbol: Tg(IL2-Il10)1Kro
• Name: transgene insertion 1, Mitchell Kronenberg
• MGI ID: MGI:2447078
• Synonyms: IL-2/IL10-Tg, mIl-10
• Transgene: Tg(IL2-Il10)1Kro Location: unknown
• Alliance: Tg(IL2-Il10)1Kro page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1 x C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(IL2-Il10)1Kro expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il10 (MGI:96537)

• Mutation details: A human IL2 promoter fused to a mouse Il10 genomic sequence was used to drive transgene expression in T lymphocytes. (J:41588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four transgenic founders were created. Two founders, 9 and 14, were used for characterization.

References

• Original: J:41588 Hagenbaugh A, et al., Altered immune responses in interleukin 10 transgenic mice. J Exp Med. 1997 Jun 16;185(12):2101-10
• All: 5 reference(s)