Dnmt3l^tm1Enl
Targeted Allele Detail

Summary

• Symbol: Dnmt3l^tm1Enl
• Name: DNA methyltransferase 3-like; targeted mutation 1, En Li
• MGI ID: MGI:2447127
• Synonyms: Dnmt3L -
• Gene: Dnmt3l Location: Chr10:77878121-77899456 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dnmt3l^tm1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75938
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-betageo cassette replaced a genomic fragment containing exons 2-7. Northern blot analysis on targeted ES cells demonstrated that no detectable transcript was expressed from this allele. (J:75938)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:	26 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3l Mutation: 52 strains or lines available

References

• Original: J:75938 Hata K, et al., Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002 Apr;129(8):1983-93
• All: 18 reference(s)