Tg(Prnp)a19Cwe
Transgene Detail

Summary

• Symbol: Tg(Prnp)a19Cwe
• Name: transgene insertion a19, Charles Weissmann
• MGI ID: MGI:2447132
• Synonyms: tga19, Tg(Prnp)19Cwe
• Transgene: Tg(Prnp)a19Cwe Location: unknown
• Alliance: Tg(Prnp)a19Cwe page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp)a19Cwe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: This transgene encodes a wild-type murine Prnp gene. Expression studies demonstrate that this line expresses Prnp transcripts in the brain 4- to 5 fold compared to wild-type. Expression patterns were similar to wild-type mice with the notable exception that transcript was not detected in Purkinje Cells. This transgenic construct, referred to as 'half genomic' was designed to omit a large intron in order to facilitate subsequent mutagenesis studies. Transgenic line 19 carries 30 copies of the integrated transgene. (J:32214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:32214 Fischer M, et al., Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J. 1996 Mar 15;15(6):1255-64
• All: 4 reference(s)