Tg(Prnp)a20Cwe
Transgene Detail

Summary

• Symbol: Tg(Prnp)a20Cwe
• Name: transgene insertion a20, Charles Weissmann
• MGI ID: MGI:2447133
• Synonyms: tg20, Tg-20, tga20
• Transgene: Tg(Prnp)a20Cwe Location: unknown
• Alliance: Tg(Prnp)a20Cwe page

Tg(Prnp*S170N*N174T)1020Aag/0 Prnp^tm1Cwe/Prnp^tm1Cwe mice develop a lethal neurologic disease with lesions in the brain and muscle

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp)a20Cwe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: This transgene encodes a wild-type mouse prion protein. Expression studies demonstrated that this line expresses Prnp transcripts in the brain 6- to 7-fold compared to wild-type. Expression patterns were similar to those of wild-type mice with the notable exception that transcript was not detected in Purkinje cells. This transgenic construct, referred to as 'half genomic,' was designed to omit a large intron in order to facilitate subsequent mutagenesis studies. (J:32214)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:32214 Fischer M, et al., Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J. 1996 Mar 15;15(6):1255-64
• All: 95 reference(s)