Tshr^tm1Rmar
Targeted Allele Detail

Summary

• Symbol: Tshr^tm1Rmar
• Name: thyroid stimulating hormone receptor; targeted mutation 1, Russell Marians
• MGI ID: MGI:2447142
• Synonyms: TSHR-KO
• Gene: Tshr Location: Chr12:91367767-91507283 bp, + strand Genetic Position: Chr12, 44.51 cM
• Alliance: Tshr^tm1Rmar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80513
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by an EGFP-neo cassette inserted by homologous recombination. The absence of normal transcript and protein in homozygous mutant mice was demonstrated by RT-PCR and Western blot analyses. GFP expression was confirmed at both the transcript and protein levels. (J:80513)

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tshr Mutation: 7 strains or lines available

References

• Original: J:80513 Marians RC, et al., Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15776-81
• All: 32 reference(s)