Tg(THY1-APP)2Somm
Transgene Detail

Summary

• Symbol: Tg(THY1-APP)2Somm
• Name: transgene insertion 2, Bernd Sommer
• MGI ID: MGI:2447145
• Synonyms: APP 22
• Transgene: Tg(THY1-APP)2Somm Location: unknown
• Alliance: Tg(THY1-APP)2Somm page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(THY1-APP)2Somm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: A human THY1 promoter and a human APP sequence carrying mutations found in Alzheimer's disease patients (Swedish double mutation K670M and N671L and London mutation V717I) was used for the transgene. In situ hybridization analysis of brain sections from transgenic animals showed the highest levels of transgene expression in the neocortex and hippocampus. (J:44603)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:44603 Sturchler-Pierrat C, et al., Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13287-92
• All: 2 reference(s)