| Affected Systems |
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behavior/neurological
|
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√
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N
|
√
|
|
√
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√
|
√
|
|
behavior/neurological phenotype
|
|
|
N
|
|
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abnormal learning/memory/conditioning
|
|
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√
|
|
abnormal habituation to a new environment
|
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|
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√
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|
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abnormal object recognition memory
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|
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√
|
|
increased exploration in new environment
|
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|
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√
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|
|
|
abnormal spatial learning
|
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|
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√
|
|
|
|
impaired spatial learning
|
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|
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√
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|
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|
|
abnormal spatial reference memory
|
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|
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√
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|
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increased aggression towards mice
|
|
|
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|
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√
|
|
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jumpy
|
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|
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|
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√
|
|
|
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abnormal locomotor activation
|
|
|
|
|
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√
|
|
|
|
abnormal locomotor circadian rhythm
|
|
|
|
|
|
√
|
|
|
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hyperactivity
|
|
√
|
|
|
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√
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√
|
|
cardiovascular system
|
|
|
|
|
√
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|
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√
|
|
abnormal brain vasculature morphology
|
|
|
|
|
|
|
|
√
|
|
vascular smooth muscle hypoplasia
|
|
|
|
|
|
|
|
√
|
|
abnormal blood circulation
|
|
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|
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|
|
√
|
|
intracerebral hemorrhage
|
|
|
|
|
√
|
|
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√
|
|
impaired blood-brain barrier function
|
|
|
|
|
|
|
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√
|
|
vascular inflammation
|
|
|
|
|
|
|
|
√
|
growth/size/body
|
|
|
|
|
|
√
|
|
|
|
decreased body weight
|
|
|
|
|
|
√
|
|
|
hematopoietic system
|
|
|
√
|
|
|
|
|
√
|
|
microgliosis
|
|
|
√
|
|
|
|
|
√
|
homeostasis/metabolism
|
√
|
|
√
|
√
|
√
|
√
|
√
|
√
|
|
amyloidosis
|
√
|
|
|
|
√
|
|
|
|
|
amyloid beta deposits
|
√
|
|
√
|
√
|
|
√
|
√
|
√
|
|
cerebral amyloid angiopathy
|
|
|
√
|
|
√
|
√
|
|
√
|
|
decreased physiological sensitivity to xenobiotic
|
|
|
|
|
|
|
|
√
|
|
abnormal response to injury
|
|
|
|
|
|
|
|
√
|
immune system
|
|
|
√
|
|
|
|
|
√
|
|
microgliosis
|
|
|
√
|
|
|
|
|
√
|
|
brain inflammation
|
|
|
|
|
|
|
|
√
|
mortality/aging
|
|
√
|
|
√
|
√
|
|
√
|
|
|
premature death
|
|
√
|
|
√
|
|
|
√
|
|
|
preweaning lethality, incomplete penetrance
|
|
|
|
|
√
|
|
|
|
muscle
|
|
|
|
|
|
|
|
√
|
|
vascular smooth muscle hypoplasia
|
|
|
|
|
|
|
|
√
|
nervous system
|
√
|
√
|
√
|
√
|
√
|
√
|
√
|
√
|
|
nervous system phenotype
|
|
|
N
|
|
|
|
|
|
|
abnormal brain vasculature morphology
|
|
|
|
|
|
|
|
√
|
|
intracerebral hemorrhage
|
|
|
|
|
√
|
|
|
√
|
|
impaired blood-brain barrier function
|
|
|
|
|
|
|
|
√
|
|
microgliosis
|
|
|
√
|
|
|
|
|
√
|
|
amyloid beta deposits
|
√
|
|
√
|
√
|
|
√
|
√
|
√
|
|
cerebral amyloid angiopathy
|
|
|
√
|
|
√
|
√
|
|
√
|
|
brain inflammation
|
|
|
|
|
|
|
|
√
|
|
abnormal hippocampus pyramidal cell morphology
|
|
|
|
|
|
|
|
√
|
|
abnormal cholinergic neuron morphology
|
|
|
|
|
|
|
|
√
|
|
abnormal axon morphology
|
|
|
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|
|
√
|
|
|
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decreased neuron number
|
|
|
|
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|
|
√
|
|
neuron degeneration
|
|
|
|
|
|
|
|
√
|
|
abnormal brain wave pattern
|
|
√
|
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√
|
|
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√
|
|
Analysis Tools
