Sox6^tm1Vlf
Targeted Allele Detail

Summary

• Symbol: Sox6^tm1Vlf
• Name: SRY (sex determining region Y)-box 6; targeted mutation 1, Veronique Lefebvre
• MGI ID: MGI:2447148
• Synonyms: Sox6^lacZ
• Gene: Sox6 Location: Chr7:115070107-115638031 bp, - strand Genetic Position: Chr7, 61.29 cM
• Alliance: Sox6^tm1Vlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80666
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a lacZ-neo-derived cassette into the second coding exon of the gene. Absence of gene expression in homozygous animals was confirmed by Northern blot analysis of whole embryo RNA. X-gal staining of mutant embryos revealed lacZ expression in cartilage tissue. (J:80666)

Expression

In Mice Carrying this Mutation:	59 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox6 Mutation: 60 strains or lines available

References

• Original: J:80666 Smits P, et al., The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001 Aug;1(2):277-90
• All: 12 reference(s)