Tg(GH)4Mi
Transgene Detail

Summary

• Symbol: Tg(GH)4Mi
• Name: transgene insertion 4, Beatrice Mintz
• MGI ID: MGI:2447156
• Synonyms: Hgh-4, Hgh4, HUGH/4, Tg.GH
• Transgene: Tg(GH)4Mi Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Tg(GH)4Mi page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Other
• Mutation details: Analyasis of genomic DNA cloned from the integration site suggests a complex rearrangement, including a probable deletion. (J:8770)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This locus and Tg(GH)3Mi are the sites of integration of the gene for human growth hormone into the DNA of mice obtained from eggs injected with the hormone gene in a plasmid vector. Heterozygotes for both insertions are normal, but homozygotes die prenatally. It is thought that disruption of native gene sequences by the insertions has inactivated the affected genes, producing recessive lethal mutations. The two mutations are not at the same locus.

References

• Original: J:7266 Wagner EF, et al., Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line. Cell. 1983 Dec;35(3 Pt 2):647-55
• All: 2 reference(s)