Lcp2^tm1Geha
Targeted Allele Detail

Summary

• Symbol: Lcp2^tm1Geha
• Name: lymphocyte cytosolic protein 2; targeted mutation 1, Raif S Geha
• MGI ID: MGI:2447170
• Synonyms: SLP-76^-
• Gene: Lcp2 Location: Chr11:33996928-34042281 bp, + strand Genetic Position: Chr11, 19.43 cM
• Alliance: Lcp2^tm1Geha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48828
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon containing the translation initiation codon was deleted and replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression was verified by Western blot analysis of thyomcytes from homozygous mutant animals. (J:48828)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcp2 Mutation: 41 strains or lines available

References

• Original: J:48828 Pivniouk V, et al., Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell. 1998 Jul 24;94(2):229-38
• All: 11 reference(s)