Snai2^tm1Look
Targeted Allele Detail

Summary

• Symbol: Snai2^tm1Look
• Name: snail family zinc finger 2; targeted mutation 1, A Thomas Look
• MGI ID: MGI:2447174
• Synonyms: Slug^-/-
• Gene: Snai2 Location: Chr16:14523716-14527249 bp, + strand Genetic Position: Chr16, 10.07 cM
• Alliance: Snai2^tm1Look page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80652
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.2 kb region of the gene encompassing exon 1 and part of exon 2 was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of mouse embryonic fibroblasts derived from homozygous mutant embryos confirmed the absence of gene expression. (J:80652)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snai2 Mutation: 35 strains or lines available

References

• Original: J:80652 Inoue A, et al., Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell. 2002 Oct;2(4):279-88
• All: 3 reference(s)