Papolb^tm1Tba
Targeted Allele Detail

Summary

• Symbol: Papolb^tm1Tba
• Name: poly (A) polymerase beta (testis specific); targeted mutation 1, Tadashi Baba
• MGI ID: MGI:2447177
• Synonyms: Tpap^-
• Gene: Papolb Location: Chr5:142513495-142515831 bp, - strand Genetic Position: Chr5, 81.53 cM, cytoband G2
• Alliance: Papolb^tm1Tba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80657
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a part of the coding region encoding 3 catalytic aspartate residues with a PGK-neo cassette. Absence of gene expression in homozygous mutant animals was confirmed by Northern and Western blot analysis of testes extracts. (J:80657)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Papolb Mutation: 21 strains or lines available

References

• Original: J:80657 Kashiwabara S, et al., Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP. Science. 2002 Dec 6;298(5600):1999-2002
• All: 1 reference(s)