Tg(Igh-6)1Msn
Transgene Detail

Summary

• Symbol: Tg(Igh-6)1Msn
• Name: transgene insertion 1, Michael S Neuberger
• MGI ID: MGI:2447191
• Synonyms: Vmu1s
• Transgene: Tg(Igh-6)1Msn Location: unknown
• Alliance: Tg(Igh-6)1Msn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-6)1Msn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igh (MGI:96442)

• Mutation details: An 11 kb construct containing a rearranged Igh-V region (a allotype) encoding a 4-hydroxy-3-nitrophenenacetyl antibody under the control of the Igh-V promoter was generated using molecular techniques. The construct was designed such that the exons encoding the Igh-6 secretory isoform were included while the exon encoding the membrane isoform was deleted. FACS analysis confirmed a lack of transgenic surface expression, while IgM comprised of transgenic Igh-6 was detected in the serum. (J:80656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80656 Baker N, et al., Cutting Edge: Selection of B Lymphocyte Subsets Is Regulated by Natural IgM. J Immunol. 2002 Dec 15;169(12):6686-90
• All: 1 reference(s)