Hpx^tm1Altr
Targeted Allele Detail

Summary

• Symbol: Hpx^tm1Altr
• Name: hemopexin; targeted mutation 1, Fiorella Altruda
• MGI ID: MGI:2447193
• Synonyms: Hx^-
• Gene: Hpx Location: Chr7:105240818-105249323 bp, - strand Genetic Position: Chr7, 55.91 cM, cytoband F1
• Alliance: Hpx^tm1Altr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58821
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a lacZ-neo cassette into the ATG start site of exon 1. Absence of gene expression in homozygous animals was confirmed by Northern blot analysis of total liver RNA. X-gal staining showed expression of lacZ in liver sections from mutant animals. (J:58821)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hpx Mutation: 31 strains or lines available

References

• Original: J:58821 Tolosano E, et al., Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. Blood. 1999 Dec 1;94(11):3906-14
• All: 17 reference(s)