Abcg2^tm1Ahs
Targeted Allele Detail

Summary

• Symbol: Abcg2^tm1Ahs
• Name: ATP binding cassette subfamily G member 2 (Junior blood group); targeted mutation 1, Alfred H Schinkel
• MGI ID: MGI:2447196
• Synonyms: Abcg2^-, Bcrp1^-
• Gene: Abcg2 Location: Chr6:58561476-58669436 bp, + strand
• Alliance: Abcg2^tm1Ahs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80519
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.1 kb genomic fragment encompassing exons 3 through 6 was replaced with a pgk-hygro selection cassette inserted by homologous recombination. The deleted region encoded the majority of the ATP-binding domain. The absence of normal transcript was confirmed by Northern blot analysis of homozygous mutant mice. No protein was detected by Western blot analysis or by immunohistochemical staining. (J:80519)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Abcg2^tm1Ahs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Abcg2 Mutation: 76 strains or lines available

References

• Original: J:80519 Jonker JW, et al., The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15649-54
• All: 43 reference(s)