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Smad4m1Mag
Chemically induced Allele Detail
Summary
Symbol: Smad4m1Mag
Name: SMAD family member 4; mutation 1, Terry Magnuson
MGI ID: MGI:2447202
Gene: Smad4  Location: Chr18:73772080-73836851 bp, - strand  Genetic Position: Chr18, 49.51 cM
Alliance: Smad4m1Mag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80520
Parent Cell Line:  CT129 (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsA transversion mutation (T to A) at nucleotide 362 resulted in an aspartic acid to glutamic acid substition. This mutation at codon 14 (D14E), in exon 1, is located just upstream of sequence encoding the Mad homology 1 domain. (J:80520)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:  47 strains or lines available
References
Original:  J:80520 Vivian JL, et al., An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15542-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory