Smad4^m1Mag
Chemically induced Allele Detail

Summary

• Symbol: Smad4^m1Mag
• Name: SMAD family member 4; mutation 1, Terry Magnuson
• MGI ID: MGI:2447202
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^m1Mag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80520
• Parent Cell Line: CT129 (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: A transversion mutation (T to A) at nucleotide 362 resulted in an aspartic acid to glutamic acid substition. This mutation at codon 14 (D14E), in exon 1, is located just upstream of sequence encoding the Mad homology 1 domain. (J:80520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:80520 Vivian JL, et al., An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15542-7
• All: 1 reference(s)