Cbfb^tm2Ppl
Targeted Allele Detail

Summary

• Symbol: Cbfb^tm2Ppl
• Name: core binding factor beta; targeted mutation 2, Pu P Liu
• MGI ID: MGI:2447293
• Synonyms: Cbfb-GFP, Cbfb^GFP
• Gene: Cbfb Location: Chr8:105897306-105944621 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cbfb^tm2Ppl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A knock-in allele was created by fusing a portion of exon 5 (amino acids 1-151) in-frame to a GFP-SV40-hygro cassette. The fusion protein exhibits the same subcellular localization pattern as wild-type and retains the ability to interact with Runx1. (J:79376)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbfb Mutation: 36 strains or lines available

References

• Original: J:79376 Kundu M, et al., Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood. 2002 Oct 1;100(7):2449-56
• All: 4 reference(s)