Kitl^Sl-2Neu
Chemically and radiation induced Allele Detail

Summary

• Symbol: Kitl^Sl-2Neu
• Name: kit ligand; steel 2 Neuherberg
• MGI ID: MGI:2447295
• Synonyms: Mgf^Sl-2Neu, Sl-1 Neu
• Gene: Kitl Location: Chr10:99851492-99936278 bp, + strand Genetic Position: Chr10, 51.4 cM
• Alliance: Kitl^Sl-2Neu page

Mutation origin

• Strain of Origin: (102/El x C3H/El)F1

Mutation description

• Allele Type: Chemically and radiation induced
• Mutation: Insertion
• Mutation details: Sequence analysis of mice homozygous for this allele showed an an 8 bp insertion of TTAACTTG at the exon 4 splice donor site, 363 bp after the start codon and predicted to result in a frameshift and truncated protein. (J:37172)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kitl Mutation: 94 strains or lines available

Notes

A mouse carrying this allele arose after sequential treatment of a (102El X C3H/El)F1 male with triethylenemelamine and gamma irradiation.

References

• Original: J:37172 Graw J, et al., Molecular analysis of two new Steel mutations in mice shows a transversion or an insertion. Mamm Genome. 1996 Nov;7(11):843-6
• All: 1 reference(s)