About   Help   FAQ
Tg(PDGFB-PSEN1)1Jhd
Transgene Detail
Summary
Symbol: Tg(PDGFB-PSEN1)1Jhd
Name: transgene insertion 1, John Hardy
MGI ID: MGI:2447324
Synonyms: PS1wt
Transgene: Tg(PDGFB-PSEN1)1Jhd  Location: unknown  
Alliance: Tg(PDGFB-PSEN1)1Jhd page
Transgene
origin
Strain of Origin:  SW x (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PDGFB-PSEN1)1Jhd expresses 1 gene
 
Mutation detailsA PDGFB promoter fused to a human PSEN1 cDNA, which includes the intron between exons 4 and 5, was used for the transgene. The PDGFB promoter was used to drive transgene expression in neurons. Transgene expression was confirmed by Northern and Western blot analysis of brain extracts derived from transgenic animals. (J:80861)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:80861 Duff K, et al., Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 1996 Oct 24;383(6602):710-3
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory