Tg(PDGFB-PSEN1M146L)2Jhd
Transgene Detail

Summary

• Symbol: Tg(PDGFB-PSEN1M146L)2Jhd
• Name: transgene insertion 2, John Hardy
• MGI ID: MGI:2447326
• Synonyms: PDGF-hPS1, PS1(M146L), PS1M146L, PS1-M146V, PS1mut, PS1 Tg line 6.2, PSlM146L
• Transgene: Tg(PDGFB-PSEN1M146L)2Jhd Location: unknown
• Alliance: Tg(PDGFB-PSEN1M146L)2Jhd page

Transgene origin

• Strain of Origin: SW x (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-PSEN1M146L)2Jhd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

• Mutation details: A PDGFB promoter fused to a human PSEN1 cDNA, which includes the intron between exons 4 and 5 and carries a methionine to leucine substitution at amino acid 146 (M146L), was used for the transgene. The PDGFB promoter was used to drive transgene expression in neurons. Transgene expression was confirmed by Northern and Western blot analysis of brain extracts derived from transgenic animals. (J:80861)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80861 Duff K, et al., Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 1996 Oct 24;383(6602):710-3
• All: 107 reference(s)