Gnaz^tm1Lfb
Targeted Allele Detail

Summary

• Symbol: Gnaz^tm1Lfb
• Name: guanine nucleotide binding protein, alpha z subunit; targeted mutation 1, Lawrence F Brass
• MGI ID: MGI:2447341
• Synonyms: Gz alpha(-)
• Gene: Gnaz Location: Chr10:74803009-74852739 bp, + strand Genetic Position: Chr10, 38.48 cM
• Alliance: Gnaz^tm1Lfb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77282
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 was replaced with a cassette containing sequence encoding enhanced GFP (EGFP) followed by neo. Normal protein was undetected by Western blot analysis of brain and platelet samples obtained from homozygous mutant mice. EGFP transcript was present in brain tissue and fluorescence was detected in platelets and megakaryocytes. (J:77282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gnaz Mutation: 18 strains or lines available

References

• Original: J:77282 Yang J, et al., Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9984-9
• All: 5 reference(s)