Tg(Gata1-Cbfb)1Tok
Transgene Detail

Summary

• Symbol: Tg(Gata1-Cbfb)1Tok
• Name: transgene insertion 1, Toshihisa Komori
• MGI ID: MGI:2447355
• Transgene: Tg(Gata1-Cbfb)1Tok Location: unknown
• Alliance: Tg(Gata1-Cbfb)1Tok page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gata1-Cbfb)1Tok expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cbfb (MGI:99851)

• Mutation details: The Gata1 promoter was used to drive mouse Cbfb (isoform 2) expression in primitive and definitive erythroid cells. Western blot analysis confirmed transgene expression in E12.5 fetal liver. (J:80668)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Cbfb^tm1Tok/Cbfb^tm1Tok Tg(Gata1-Cbfb)1Tok/0	involves: 129P2/OlaHsd * C57BL/6J

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms
cardiovascular system	N
cardiovascular system phenotype	N
cellular	√
arrested osteoblast differentiation	√
endocrine/exocrine glands	√
small thymus	√
growth/size/body	√
abnormal chest morphology	√
proportional dwarf	√
hematopoietic system	√
small thymus	√
abnormal definitive hematopoiesis	√
decreased lymphocyte cell number	√
absent T cells	√
small spleen	√
immune system	√
small thymus	√
decreased lymphocyte cell number	√
absent T cells	√
small spleen	√
limbs/digits/tail	√
short limbs	√
mortality/aging	√
perinatal lethality, complete penetrance	√
respiratory system	√
respiratory failure	√
skeleton	√
arrested osteoblast differentiation	√
absent clavicle	√
abnormal long bone hypertrophic chondrocyte zone	√
abnormal bone ossification	√
delayed endochondral bone ossification	√
abnormal intramembranous bone ossification	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80668 Yoshida CA, et al., Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002 Dec;32(4):633-8
• All: 2 reference(s)