Tg(Trp53A135V)L3Ber
Transgene Detail

Summary

• Symbol: Tg(Trp53A135V)L3Ber
• Name: transgene insertion L3, Alan Bernstein
• MGI ID: MGI:2447408
• Synonyms: pL53-3, Tg(pL53)3Ber, Tg(Trp53A135V)2Ber
• Transgene: Tg(Trp53A135V)L3Ber Location: unknown
• Alliance: Tg(Trp53A135V)L3Ber page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Trp53A135V)L3Ber expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trp53 (MGI:98834)

• Mutation details: The transgene contains the mouse transformation related protein 53 promoter and an allele of the mouse Trp53 gene that carries a point mutation in codon 135 (GCG to GTG), resulting in an alanine to valine substitution. The Trp53 promoter drove high levels of transgenic expression in the spleen, thymus, and lymph nodes. Transgenic expression was also reported in the ovaries. Little or no expression was reported to have been observed in the liver and lungs of these mice. (J:19870)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Trp53A135V)L3Ber

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Additional lines L1 and L2 were produced.

Homozygous transgenic mice are viable and fertile, but show a high incidence of tumors, particularly lung adenocarcinomas, osteosarcomas, and lymphomas.

References

• Original: J:19870 Lavigueur A, et al., High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol. 1989 Sep;9(9):3982-91
• All: 4 reference(s)