Tsg101^tm1Kuw
Targeted Allele Detail

Summary

• Symbol: Tsg101^tm1Kuw
• Name: tumor susceptibility gene 101; targeted mutation 1, Kay-Uwe Wagner
• MGI ID: MGI:2447442
• Synonyms: Tsg101^fl
• Gene: Tsg101 Location: Chr7:46538697-46569717 bp, - strand Genetic Position: Chr7, 30.62 cM, cytoband B5
• Alliance: Tsg101^tm1Kuw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80891
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked by a floxed neo cassette inserted approximately 3 kb upstream and a single loxP site inserted 230 bp into intron 1. Phenotypic analysis indicated that the insertion of the neo cassette did not significantly intefere with transcription. (J:80891)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tsg101 Mutation: 32 strains or lines available

References

• Original: J:80891 Wagner KU, et al., Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol Cell Biol. 2003 Jan;23(1):150-62
• All: 8 reference(s)