Tg(PSEN1)S8-4Dbo
Transgene Detail

Summary

• Symbol: Tg(PSEN1)S8-4Dbo
• Name: transgene insertion S8-4, David R Borchelt
• MGI ID: MGI:2447452
• Synonyms: S8-4, Tg(PSEN1)1Dbo, wildtype Hu PS1
• Transgene: Tg(PSEN1)S8-4Dbo Location: unknown
• Alliance: Tg(PSEN1)S8-4Dbo page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PSEN1)S8-4Dbo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

• Mutation details: The transgene consists of a mouse prion promoter and a cDNA encoding wild-type human presenilin 1. Transgene expression was verified by Northern and Western blot analysis of brain extracts derived from transgenic animals. Lines S8-4, R8-1, H8-4, and B8-1 were generated. (J:34323)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Several transgenic lines were created. S8-4 is one of the highest expressing lines.

References

• Original: J:34323 Thinakaran G, et al., Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 1996 Jul;17(1):181-90
• All: 12 reference(s)