Tg(MMTV-Myc)141-3Led
Transgene Detail

Summary

• Symbol: Tg(MMTV-Myc)141-3Led
• Name: transgene insertion 141-3, Philip Leder
• MGI ID: MGI:2447500
• Synonyms: 141-3, M strain, MTV-H3 141-3, TG.M
• Transgene: Tg(MMTV-Myc)141-3Led Location: unknown
• Alliance: Tg(MMTV-Myc)141-3Led page

Transgene origin

• Strain of Origin: (CD-1 x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Myc)141-3Led expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Mutation details: This transgene contains the MMTV (mouse mammary tumor virus) promoter and the mouse Myc (myelocytomatosis) oncogene. The construct is also called "MTV-H3 myc." The transgene was expressed in salivary gland, intestine, and mammary gland. Expression of the transgene was not detected in thymus, pancreas, spleen, kidney, testis, liver, heart, lung, muscle, brain, or preputial gland. (J:29013)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Myc)141-3Led

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Lines 139-1, 143-3, and 143-5 also carry this construct. The construct is also called "MMTV/c-myc'" "MTV-H3" "MTV-H3 myc" or "MMTV-H3 myc" or "TG.M."

References

• Original: J:29013 Stewart TA, et al., Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell. 1984 Oct;38(3):627-37
• All: 33 reference(s)