Rnf2^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Rnf2^tm1Hko
• Name: ring finger protein 2; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:2447529
• Synonyms: Ring1B^red
• Gene: Rnf2 Location: Chr1:151345159-151376562 bp, - strand Genetic Position: Chr1, 64.15 cM
• Alliance: Rnf2^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79851
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: The authors generated a hypomorphic Rnf2 allele using gene targeting. No genomic sequence was deleted. However, a Neo cassette and 0.8 kb of one of the homology arms were inserted between exons 3 and 4. The inserted sequence was from 3' UTS. Protein levels in the homozygous mutant were 30% of those in the heterozygous mutant. (J:79851)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rnf2 Mutation: 36 strains or lines available

References

• Original: J:79851 Suzuki M, et al., Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development. 2002 Sep;129(18):4171-83
• All: 2 reference(s)