Tg(SFTPC-RAF1)87Urr
Transgene Detail

Summary

• Symbol: Tg(SFTPC-RAF1)87Urr
• Name: transgene insertion 87, Ulf R Rapp
• MGI ID: MGI:2447566
• Synonyms: SP-C-c-Raf-1-87
• Transgene: Tg(SFTPC-RAF1)87Urr Location: unknown
• Alliance: Tg(SFTPC-RAF1)87Urr page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-RAF1)87Urr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RAF1 (5894)

  Raf1	(MGI:97847)

• Mutation details: The transgene is composed of a human SFTPC promoter, a human RAF1 cDNA, and an SV40 small T antigen intron and polyadenylation signal. 3.7 kb of human SFTPC promoter sequences was used to drive transgene expression in lung epithelium. (J:80895)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

11 independent transgenic lines were created. This line is a representative of the lines in which all mice develop lung adenomas and no hydronephrosis.

References

• Original: J:80895 Kerkhoff E, et al., Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. Cell Growth Differ. 2000 Apr;11(4):185-90
• All: 3 reference(s)