Tg(LCKprBCL2)36Sjk
Transgene Detail

Summary

• Symbol: Tg(LCKprBCL2)36Sjk
• Name: transgene insertion 36, Stanley J Korsmeyer
• MGI ID: MGI:2447592
• Synonyms: Lck-Bcl-2, Lck-BCL2, lck^pr-bcl-2, prLck.hbcl-2
• Transgene: Tg(LCKprBCL2)36Sjk Location: unknown
• Alliance: Tg(LCKprBCL2)36Sjk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LCKprBCL2)36Sjk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: The transgene consists of 0.75 kb of Lck proximal promoter sequences (active in lymphoid tissues) and 3.2 kb of human BCL2 cDNA. Introns, exons, and polyadenylation sequences from the human growth hormone gene consitutes the 3' untranslated region of the construct. Transgene expression in the thymus, lymph nodes, and spleen was verified by Western blot analysis and immunohistochemistry. Seven transgenic lines were established with lines 7, 17, and 36 expressing the transgene at high levels. (J:11548)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:11548 Sentman CL, et al., bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell. 1991 Nov 29;67(5):879-88
• All: 54 reference(s)