Hspa2^tm1Dix
Targeted Allele Detail

Summary

• Symbol: Hspa2^tm1Dix
• Name: heat shock protein 2; targeted mutation 1, David J Dix
• MGI ID: MGI:2447605
• Synonyms: Hsp70-2^-
• Gene: Hspa2 Location: Chr12:76450950-76453712 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Hspa2^tm1Dix page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35110
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of testicular tissue obtained from homozygous mutant mice. Immunostaining of testicular sections indicated an absence of normal protein in seminiferous tubules. (J:35110)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hspa2 Mutation: 24 strains or lines available

References

• Original: J:35110 Dix DJ, et al., Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3264-8
• All: 9 reference(s)