Hey2^tm1Mtc
Targeted Allele Detail

Summary

• Symbol: Hey2^tm1Mtc
• Name: hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Michael T Chin
• MGI ID: MGI:2447620
• Synonyms: CHF1^-
• Gene: Hey2 Location: Chr10:30708355-30718779 bp, - strand Genetic Position: Chr10, 17.19 cM, cytoband A4
• Alliance: Hey2^tm1Mtc page

Hey2^tm1Mtc/Hey2^tm1Mtc mice have ventricular septal defects

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80681
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing 551 nt of the proximal promoter and exon 1 through the majority of exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 75 residues composing the amino terminal, basic region, and most of the helix-loop-helix domain. Transcript was undetected by RT-PCR analysis of cardiac ventricles obtained from homozygous mutant embryos. (J:80681)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hey2 Mutation: 31 strains or lines available

References

• Original: J:80681 Sakata Y, et al., Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16197-202
• All: 8 reference(s)