Dlx5/Dlx6^tm1Levi
Targeted Allele Detail

Summary

• Symbol: Dlx5/Dlx6^tm1Levi
• Name: distal-less homeobox 5; targeted mutation 1, Giovanni Levi
• MGI ID: MGI:2447624
• Synonyms: Dlx5/6^-, Dlx5-Dlx6^-
• Gene: Dlx5 Location: Chr6:6877801-6882068 bp, - strand Genetic Position: Chr6, 2.83 cM
• Alliance: Dlx5/Dlx6^tm1Levi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77244
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Coding regions of both Dlx5 and Dlx6 were deleted and replaced with lacZ-floxed-RSV-neo construct via a single homologous recombination event. The gene targeting event also generated a transcriptionally silent genomic duplication spanning both Dlx5 and Dxl6. Absence of gene expression was confirmed by RT-PCR and whole mount in situ hybridization. (J:77244)

Disease models

Expression

In Mice Carrying this Mutation:	81 assay results
In Structures Affected by this Mutation:	34 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlx5 Mutation: 25 strains or lines available

References

• Original: J:77244 Merlo GR, et al., Mouse model of split hand/foot malformation type I. Genesis. 2002 Jun;33(2):97-101
• All: 21 reference(s)