Runx1^tm1Tani
Targeted Allele Detail

Summary

• Symbol: Runx1^tm1Tani
• Name: runt related transcription factor 1; targeted mutation 1, Ichiro Taniuchi
• MGI ID: MGI:2447630
• Synonyms: Runx1^F
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm1Tani page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80690
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was floxed by insertion of a single upstream loxP site and a downstream floxed neo cassette. The neo cassette was subsequently removed by transient expression of cre recombinase in correctly targeted ES cells, leaving exon 4 flanked by loxP sites. (J:80690)

Expression

In Mice Carrying this Mutation:

5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:80690 Taniuchi I, et al., Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development. Cell. 2002 Nov 27;111(5):621-33
• All: 31 reference(s)