Kcnj3^tm1Kwn
Targeted Allele Detail

Summary

• Symbol: Kcnj3^tm1Kwn
• Name: potassium inwardly-rectifying channel, subfamily J, member 3; targeted mutation 1, Kevin D Wickman
• MGI ID: MGI:2447632
• Synonyms: GIRK1 KO, Kir3.1 knock-out
• Gene: Kcnj3 Location: Chr2:55325982-55488157 bp, + strand Genetic Position: Chr2, 31.66 cM
• Alliance: Kcnj3^tm1Kwn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was deleted by homologous and cre mediated recombination in ES cells. The deleted sequence encoded the pore and transmembrane domains, the entire amino terminus, and the initiator methionine. Normal protein was undetected by Western blot analysis of atrial tissue obtained from homozygous mutant mice. (J:80714)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnj3 Mutation: 33 strains or lines available

References

• Original: J:80714 Bettahi I, et al., Contribution of the Kir3.1 Subunit to the Muscarinic-gated Atrial Potassium Channel IKACh. J Biol Chem. 2002 Dec 13;277(50):48282-8
• All: 19 reference(s)