Tg(Mx1-IL11)1Tku
Transgene Detail

Summary

• Symbol: Tg(Mx1-IL11)1Tku
• Name: transgene insertion 1, Yasuhiro Takeuchi
• MGI ID: MGI:2447666
• Transgene: Tg(Mx1-IL11)1Tku Location: unknown
• Alliance: Tg(Mx1-IL11)1Tku page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mx1-IL11)1Tku expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL11 (3589)

  Il11	(MGI:107613)

• Mutation details: An inducible Mx1 promoter and a 762 bp DNA fragment containing the coding region of human IL11 was used for the transgene. The Mx1 promoter was included for transgene induction by interferon alpha/beta. Since the transgenic animals constitutively expressed human IL11, interferon induction was not implemented. The 3' untranslated region of the transgene contains exons, introns, and polyadenylation sequences from human GH. Transgene expression is constitutively active in several tissues examined by RT-PCR. Furthermore, Northern blot analysis detected transgene expression in the long bone of transgenic animals. (J:80706)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80706 Takeuchi Y, et al., Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. J Biol Chem. 2002 Dec 13;277(50):49011-8
• All: 1 reference(s)