Pmp22^tm1Ueli
Targeted Allele Detail

Summary

• Symbol: Pmp22^tm1Ueli
• Name: peripheral myelin protein 22; targeted mutation 1, Ueli Suter
• MGI ID: MGI:2447704
• Synonyms: Pmp22-, Pmp22⁰, Pmp22^ko
• Gene: Pmp22 Location: Chr11:63019808-63050373 bp, + strand Genetic Position: Chr11, 38.99 cM
• Alliance: Pmp22^tm1Ueli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neo-derived cassette into exon 2 at amino acid 8. Absence of gene expression was confirmed by Western blot analysis of sciatic nerve homogenates from ten-week old homozygous mutant animals using antibodies directed against residues 117-132 of the protein. (J:29517)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pmp22 Mutation: 33 strains or lines available

References

• Original: J:29517 Adlkofer K, et al., Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice. Nat Genet. 1995 Nov;11(3):274-80
• All: 21 reference(s)