Tg(BLG-STAT5A)6Itb
Transgene Detail

Summary

• Symbol: Tg(BLG-STAT5A)6Itb
• Name: transgene insertion 6, Itamar Barash
• MGI ID: MGI:2447716
• Synonyms: BGL/STAT5, Tg(BLG-STAT5A)1Itb
• Transgene: Tg(BLG-STAT5A)6Itb Location: unknown
• Alliance: Tg(BLG-STAT5A)6Itb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(BLG-STAT5A)6Itb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  sheep	STAT5A (443419)

• Mutation details: The transgene consists of a beta-lactoglobulin promoter, active in mammary glands, and the wild-type sheep STAT5A gene. Transgene expression was confirmed by Western blot analysis of mammary glands from transgenic animals at day 6 of lactation. (J:80588)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This is transgenic line BGL/STAT5a-6. Line BGL/STAT5a-8 was also created. Line BGL/STAT5a-6 carries 4 copies of the integrated transgene, and line BGL/STAT5a-8 carries 2 copies.

References

• Original: J:80588 Iavnilovitch E, et al., Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis. Mol Cancer Res. 2002 Nov;1(1):32-47
• All: 1 reference(s)