Tbx6^tm1Pa
Targeted Allele Detail

Summary

• Symbol: Tbx6^tm1Pa
• Name: T-box 6; targeted mutation 1, Virginia Papaioannou
• MGI ID: MGI:2447721
• Gene: Tbx6 Location: Chr7:126380655-126384720 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Tbx6^tm1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80954
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing all of exons 1 and 2 and a portion of exon 3 was replaced by a neo cassette inserted by homologous recombination. The deleted region encoded the initiator methionine and the DNA-binding domain of the T-box. (J:80954)

Expression

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx6 Mutation: 17 strains or lines available

References

• Original: J:80954 Chapman DL, et al., Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
• All: 13 reference(s)